Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland. Centre for Population Health Research, Turku University Hospital, University of Turku, 20520 Turku, Finland. Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, 20520 Turku, Finland. Heart Center, Turku University Hospital, University of Turku, 20520 Turku, Finland. Department of Pediatrics and Adolescent Medicine, Turku University Hospital, University of Turku, 20520 Turku, Finland. Department of Public Health, Turku University Hospital, University of Turku, 20520 Turku, Finland. Division of Medicine, Department of Medicine, Turku University Hospital, University of Turku, 20520 Turku, Finland. Department of Chronic Disease Prevention, Institute for Health and Welfare, 20750 Turku, Finland. Computational Medicine, Faculty of Medicine, University of Oulu & Biocenter Oulu, 90014 Oulu, Finland. NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, 70210 Kuopio, Finland. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, University of Turku, 20520 Turku, Finland.